The pathophysiology of glaucoma is complex, multifactorial and not completely understood.
Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic …

AMP-activated protein kinase (AMPK), a member of the serine/threonine (Ser/Thr) kinase
group, is universally distributed in various cells and organs. It is a significant endogenous …

The retina, owing to its cellular anatomy and physical location, is susceptible to generating
reactive oxygen species (ROS), which are associated with several major retinal diseases …

Polyunsaturated fatty acids (PUFA) are known to have numerous beneficial effects, owing to
their anti-inflammatory and antioxidant properties. From a metabolic standpoint, the …

The extracellular matrix (ECM) is a diverse microenvironment that maintains bidirectional
communication with surrounding cells to regulate cell and tissue homeostasis. The classical …

Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness
worldwide. Increasing evidence suggests oxidative damage and immune response defects …

Given the expanding elderly population in the United States and the world, it is important to
understand the processes underlying both natural and pathological age-related changes in …

Extra virgin olive oil (EVOO) from Olea europaea (cultivated olive tree) and the oil obtained
from the wild olive variety or acebuche (ACE oil from Olea oleaster) contain an extraordinary …

Background Glaucoma is the leading cause of irreversible blindness worldwide. Emerged
evidence has shown that glaucoma is considered an immune system related disorder. The …

Background: Primary open-angle glaucoma (POAG) is a multifactorial pathology involving a
variety of pathogenic mechanisms, including oxidative/nitrosative stress. This latter is the …