As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-
competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles …

Studies on synaptic proteins involved in neurotransmitter release often aim at distinguishing
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …

During ongoing presynaptic action potential (AP) firing, transmitter release is limited by the
availability of release-ready synaptic vesicles (SVs). The rate of SV recruitment (SVR) to …

α-Synuclein is expressed at high levels at presynaptic terminals, but defining its role in the
regulation of neurotransmission under physiologically relevant conditions has proven …

Pre-and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic
mechanisms underlying learning and memory. At layer 5 pyramidal neurons, LTP increases …

Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain
reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar …

During prolonged trains of presynaptic action potentials (APs), synaptic release reaches a
stable level that reflects the speed of replenishment of the readily releasable pool (RRP) …

The Ca 2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are
fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite …

Chemical synaptic transmission relies on the Ca2+-induced fusion of transmitter-laden
vesicles whose coupling distance to Ca2+ channels determines synaptic release probability …

The concentration of calcium ions in presynaptic terminals regulates transmitter release, but
underlying mechanisms have remained unclear. Here we review recent studies that shed …