Wnt/β-catenin signaling inhibitors
X Zhang, N Dong, X Hu - Current topics in medicinal chemistry, 2023 - ingentaconnect.com
The Wnt/β-catenin signaling pathway plays a crucial role in the development, tissue
homeostasis, angiogenesis, and carcinogenesis of cancer. Mutations and excessive …
homeostasis, angiogenesis, and carcinogenesis of cancer. Mutations and excessive …
HOTAIR: A key regulator of the Wnt/β-catenin signaling cascade in cancer progression and treatment
MA Hakami, A Hazazi, O Abdulaziz… - … -Research and Practice, 2024 - Elsevier
The long non-coding RNA (lncRNA) HOTAIR occupies a central position in the complex
domain of cancer biology, particularly concerning its intricate interplay with the Wnt/β …
domain of cancer biology, particularly concerning its intricate interplay with the Wnt/β …
Ursolic acid suppresses colorectal cancer by down-regulation of Wnt/β-catenin signaling pathway activity
H Zhao, S Tang, Q Tao, T Ming, J Lei… - Journal of agricultural …, 2023 - ACS Publications
Overwhelming evidence points to an abnormally active Wnt/β-catenin signaling as a key
player in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA) is a pentacyclic …
player in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA) is a pentacyclic …
Roles of PPAR activation in cancer therapeutic resistance: Implications for combination therapy and drug development
Y Zhang, B Xiao, Y Liu, S Wu, Q Xiang, Y Xiao… - European Journal of …, 2024 - Elsevier
Therapeutic resistance is a major obstacle to successful treatment or effective containment
of cancer. Peroxisome proliferator-activated receptors (PPARs) play an essential role in …
of cancer. Peroxisome proliferator-activated receptors (PPARs) play an essential role in …
Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights
Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can
infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well …
infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well …
Cells of the tumor microenvironment speak the Wnt language
VL Katanaev, A Baldin, TV Denisenko… - Trends in Molecular …, 2023 - cell.com
Wnt signaling plays numerous functions in cancer, from primary transformation and tumor
growth to metastasis. In addition to these cancer cell-intrinsic functions, Wnt signaling …
growth to metastasis. In addition to these cancer cell-intrinsic functions, Wnt signaling …
Harnessing Drug Repurposing to Combat Breast Cancer by Targeting Altered Metabolism and Epithelial-to-Mesenchymal Transition Pathways
Breast cancer remains one of the most prevalent and challenging cancers to treat due to its
complexity and heterogenicity. Cellular processes such as metabolic reprogramming and …
complexity and heterogenicity. Cellular processes such as metabolic reprogramming and …
Targeting the NOTCH2/ADAM10/TCF7L2 Axis‐Mediated Transcriptional Regulation of Wnt Pathway Suppresses Tumor Growth and Enhances Chemosensitivity in …
Z Xiang, Y Wang, X Ma, S Song, Y He, J Zhou… - Advanced …, 2024 - Wiley Online Library
Wnt/β‐catenin/transcription factor (TCF) transcriptional activity plays an integral role in
colorectal cancer (CRC) carcinogenesis. However, to date, no drugs targeting this pathway …
colorectal cancer (CRC) carcinogenesis. However, to date, no drugs targeting this pathway …
LGR5 expression predicting poor prognosis is negatively correlated with WNT5A in colon cancer
LM Mehdawi, S Ghatak, P Chakraborty, A Sjölander… - Cells, 2023 - mdpi.com
WNT/β-catenin signaling is essential for colon cancer development and progression.
WNT5A (ligand of non-canonical WNT signaling) and its mimicking peptide Foxy5 impair β …
WNT5A (ligand of non-canonical WNT signaling) and its mimicking peptide Foxy5 impair β …
Targeting membrane trafficking as a strategy for cancer treatment
N Tejeda-Muñoz, KC Mei, P Sheladiya, J Monka - Vaccines, 2022 - mdpi.com
Membrane trafficking is emerging as an attractive therapeutic strategy for cancer. Recent
reports have found a connection between Wnt signaling, receptor-mediated endocytosis, V …
reports have found a connection between Wnt signaling, receptor-mediated endocytosis, V …