Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine
kinase initially found to be expressed in a wide range of early embryonic cellular stages, and …

Neural stem cells self-renew and give rise to neurons, astrocytes and oligodendrocytes.
These cells hold great promise for neural repair after injury or disease. However, a great …

Understanding the cell–cell interactions that control CNS development and function has
long been limited by the lack of methods to cleanly separate neural cell types. Here we …

Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and
discovered to resemble stages in neurogenesis. One tumor class displaying neuronal …

Cancer stem cells are rare tumor cells characterized by their ability to self-renew and to
induce tumorigenesis. They are present in gliomas and may be responsible for the lethality …

Glioblastoma multiforme (GBM) is a life-threatening brain tumor. Accumulating evidence
suggests that eradication of glioma stem-like cells (GSCs) in GBM is essential to achieve …

Previous studies have demonstrated that a small subpopulation of brain tumor cells share
key characteristics with neural stem/progenitor cells in terms of phenotype and behavior …

Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in
therapy resistance. Previously, we reported that the mitotic kinase MELK binds and …

The Maternal Embryonic Leucine Zipper Kinase (MELK) has been reported to be a genetic
dependency in several cancer types. MELK RNAi and small-molecule inhibitors of MELK …

Lung cancer is the fastest growth rate of morbidity and mortality in nearly a decade, and
remains difficult to treat. Furthermore, the molecular mechanisms underlying its development …