Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
[HTML][HTML] Endothelial glycocalyx
The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …
primarily conformed of glycoproteins and proteoglycans, which provide communication …
Endothelial shear stress signal transduction and atherogenesis: from mechanisms to therapeutics
Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …
[HTML][HTML] Phenotypic diversity and metabolic specialization of renal endothelial cells
Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …
the survival of the whole organism. The kidneys play a critical part in this process through …
The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis
F Lupu, G Kinasewitz, K Dormer - Journal of cellular and …, 2020 - Wiley Online Library
Sepsis is a multifactorial syndrome primarily determined by the host response to an invading
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …
Endothelial mechanobiology in atherosclerosis
X Wang, Y Shen, M Shang, X Liu… - Cardiovascular …, 2023 - academic.oup.com
Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …
Response of cells and tissues to shear stress
JA Espina, MH Cordeiro, M Milivojevic… - Journal of Cell …, 2023 - journals.biologists.com
Shear stress is essential for normal physiology and malignancy. Common physiological
processes–such as blood flow, particle flow in the gut, or contact between migratory cell …
processes–such as blood flow, particle flow in the gut, or contact between migratory cell …
Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients
The severe forms and worsened outcomes of COVID-19 (coronavirus disease 19) are
closely associated with hypertension and cardiovascular disease. Endothelial cells express …
closely associated with hypertension and cardiovascular disease. Endothelial cells express …
[HTML][HTML] Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study
A Rovas, J Sackarnd, J Rossaint, S Kampmeier… - Critical Care, 2021 - Springer
Background The availability of handheld, noninvasive sublingual video-microscopes allows
for visualization of the microcirculation in critically ill patients. Recent studies demonstrate …
for visualization of the microcirculation in critically ill patients. Recent studies demonstrate …
Adaptable microfluidic vessel-on-a-chip platform for investigating tumor metastatic transport in bloodstream
Cancer metastasis counts for 90% of cancer fatalities, and its development process is still a
mystery. The dynamic process of tumor metastatic transport in the blood vessel is not well …
mystery. The dynamic process of tumor metastatic transport in the blood vessel is not well …