Melanoma represents the most aggressive and the deadliest form of skin cancer. Current
therapeutic approaches include surgical resection, chemotherapy, photodynamic therapy …

These are exciting times for cancer immunotherapy. After many years of disappointing
results, the tide has finally changed and immunotherapy has become a clinically validated …

Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …

Gene therapy is a promising strategy for specific treatment of numerous gene-associated
human diseases by intentionally altering the gene expression in pathological cells. A …

CRISPR/Cas9 genome editing platforms are widely applied as powerful tools in basic
research and potential therapeutics for genome regulation. The appropriate alternative of …

Melanoma often spreads to cutaneous or subcutaneous sites that are amenable to direct,
intralesional injection. As such, developing effective injectable agents has been of …

PURPOSE We evaluated the activity of intratumoral Coxsackievirus A21 (V937) in 57
patients with unresectable stage IIIC or IV melanoma. PATIENTS AND METHODS In this …

Talimogene laherparepvec (Imlygic™) is an oncolytic viral therapy that is being developed
by BioVex (a subsidiary of Amgen) for the intralesional treatment of various cancers …

Melanoma is a relentless type of skin cancer which involves myriad signaling pathways
which regulate many cellular processes. This makes melanoma difficult to treat, especially …

Oncolytic herpes simplex virus (oHSV) was one of the first genetically-engineered oncolytic
viruses. Because HSV is a natural human pathogen that can cause serious disease, it is …