Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

Insulin, a key peptide hormone that conjointly with its receptor regulates blood glucose
levels, is used as the major means to treat diabetes. This therapeutic hormone may undergo …

The presence and biological significance of circulating glycated insulin has been evaluated
by high-pressure liquid chromatography (HPLC), electrospray ionization mass spectrometry …

This study was conducted to evaluate the responsiveness of human nonpregnant
myometrium to endothelin 1 (ET1)(10 (-10) M-10 (-6) M) and KCl (80 mM) in relation to the …

Hyperglycemic condition in diabetes promotes glycation of various plasma proteins
including insulin. Glycation of insulin has been reported to reduce its biological activity …

The vascular diseases, hypertension and atherosclerosis, affect millions of individuals
worldwide, and account for a large number of deaths globally. A better understanding of the …

Curcumin is known for its anti-inflammatory, antioxidant and anticancer activity, as well as for
its ability to interfere with amyloid aggregation and non-enzymatic glycation reaction, that …

Non-enzymatic glycation of proteins is a post-translational modification produced by a
reaction between reducing sugars and amino groups located in lysine and arginine residues …

Previous studies have shown that glycated insulin is secreted from pancreatic β-cells under
conditions of hyperglycaemia. This study has investigated the effects of monoglycated …

Insulin is a key hormone regulating glucose homeostasis, intimately associated with
glycemia and is exposed to glycation by glucose, reducing sugars and other highly reactive …