Understanding the role of protein glycation in the amyloid aggregation process
I Sirangelo, C Iannuzzi - International Journal of Molecular Sciences, 2021 - mdpi.com
Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …
elements and any alteration in protein architecture leads to several abnormalities and …
Chemical modifications of insulin: Finding a compromise between stability and pharmaceutical performance
M Akbarian, Y Ghasemi, VN Uversky… - International journal of …, 2018 - Elsevier
Insulin, a key peptide hormone that conjointly with its receptor regulates blood glucose
levels, is used as the major means to treat diabetes. This therapeutic hormone may undergo …
levels, is used as the major means to treat diabetes. This therapeutic hormone may undergo …
Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycemic-hyperinsulinemic clamp technique in humans
SJ Hunter, AC Boyd, FPM O'Harte, AM McKillop… - Diabetes, 2003 - Am Diabetes Assoc
The presence and biological significance of circulating glycated insulin has been evaluated
by high-pressure liquid chromatography (HPLC), electrospray ionization mass spectrometry …
by high-pressure liquid chromatography (HPLC), electrospray ionization mass spectrometry …
The balance between gluco-and mineralo-corticoid action critically determines inflammatory adipocyte responses
J Hoppmann, N Perwitz, B Meier… - Journal of …, 2010 - joe.bioscientifica.com
This study was conducted to evaluate the responsiveness of human nonpregnant
myometrium to endothelin 1 (ET1)(10 (-10) M-10 (-6) M) and KCl (80 mM) in relation to the …
myometrium to endothelin 1 (ET1)(10 (-10) M-10 (-6) M) and KCl (80 mM) in relation to the …
[HTML][HTML] Molecular investigation of glycated insulin-induced insulin resistance via insulin signaling and AGE-RAGE axis
PB Walke, SB Bansode, NP More… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Hyperglycemic condition in diabetes promotes glycation of various plasma proteins
including insulin. Glycation of insulin has been reported to reduce its biological activity …
including insulin. Glycation of insulin has been reported to reduce its biological activity …
Role of advanced glycation end products in hypertension and atherosclerosis: therapeutic implications
S Vasdev, V Gill, P Singal - Cell biochemistry and biophysics, 2007 - Springer
The vascular diseases, hypertension and atherosclerosis, affect millions of individuals
worldwide, and account for a large number of deaths globally. A better understanding of the …
worldwide, and account for a large number of deaths globally. A better understanding of the …
Vanillin affects amyloid aggregation and non-enzymatic glycation in human insulin
C Iannuzzi, M Borriello, G Irace, M Cammarota… - Scientific Reports, 2017 - nature.com
Curcumin is known for its anti-inflammatory, antioxidant and anticancer activity, as well as for
its ability to interfere with amyloid aggregation and non-enzymatic glycation reaction, that …
its ability to interfere with amyloid aggregation and non-enzymatic glycation reaction, that …
Glycation isotopic labeling with 13C-reducing sugars for quantitative analysis of glycated proteins in human plasma
F Priego-Capote, A Scherl, M Möller, P Waridel… - Molecular & Cellular …, 2010 - ASBMB
Non-enzymatic glycation of proteins is a post-translational modification produced by a
reaction between reducing sugars and amino groups located in lysine and arginine residues …
reaction between reducing sugars and amino groups located in lysine and arginine residues …
Impaired ability of glycated insulin to regulate plasma glucose and stimulate glucose transport and metabolism in mouse abdominal muscle
AC Boyd, YHA Abdel-Wahab, AM McKillop… - … et Biophysica Acta (BBA …, 2000 - Elsevier
Previous studies have shown that glycated insulin is secreted from pancreatic β-cells under
conditions of hyperglycaemia. This study has investigated the effects of monoglycated …
conditions of hyperglycaemia. This study has investigated the effects of monoglycated …
[HTML][HTML] D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts
C Iannuzzi, M Borriello, V Carafa, L Altucci… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Insulin is a key hormone regulating glucose homeostasis, intimately associated with
glycemia and is exposed to glycation by glucose, reducing sugars and other highly reactive …
glycemia and is exposed to glycation by glucose, reducing sugars and other highly reactive …