The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Abstract Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that has
important roles in regulating energy balance and glucose and lipid homeostasis through a …
important roles in regulating energy balance and glucose and lipid homeostasis through a …
Metabolic messengers: FGF21
KH Flippo, MJ Potthoff - Nature metabolism, 2021 - nature.com
As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as
an endocrine hormone that signals to distinct targets throughout the body. Interest in …
an endocrine hormone that signals to distinct targets throughout the body. Interest in …
[HTML][HTML] Hepatokines and metabolism: Deciphering communication from the liver
SO Jensen-Cody, MJ Potthoff - Molecular metabolism, 2021 - Elsevier
Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
Understanding the physiology of FGF21
FM Fisher, E Maratos-Flier - Annual review of physiology, 2016 - annualreviews.org
Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
Fibroblast growth factor 21—metabolic role in mice and men
H Staiger, M Keuper, L Berti… - Endocrine …, 2017 - academic.oup.com
Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …
Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling
Canonical fibroblast growth factors (FGFs) activate FGF receptors (FGFRs) through
paracrine or autocrine mechanisms in a process that requires cooperation with heparan …
paracrine or autocrine mechanisms in a process that requires cooperation with heparan …
[HTML][HTML] A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis
Q Pan, S Lin, Y Li, L Liu, X Li, X Gao, J Yan, B Gu… - …, 2021 - thelancet.com
Background Fibroblast growth factor 21 (FGF21) has become a promising therapeutic target
for metabolic diseases such as type 2 diabetes (T2D), obesity and non-alcoholic …
for metabolic diseases such as type 2 diabetes (T2D), obesity and non-alcoholic …
[HTML][HTML] FGF19 and FGF21 for the treatment of NASH—two sides of the same coin? Differential and overlapping effects of FGF19 and FGF21 from mice to human
E Henriksson, B Andersen - Frontiers in Endocrinology, 2020 - frontiersin.org
FGF19 and FGF21 analogues are currently in clinical development for the potential
treatment of NASH. In Phase 2 clinical trials analogues of FGF19 and FGF21 decrease …
treatment of NASH. In Phase 2 clinical trials analogues of FGF19 and FGF21 decrease …
[HTML][HTML] Inventing new medicines: the FGF21 story
A Kharitonenkov, AC Adams - Molecular metabolism, 2014 - Elsevier
Since the discovery of insulin in 1921, protein therapeutics have become vital tools in the
treatment of diabetes mellitus. This heritage has been extended with the comparatively …
treatment of diabetes mellitus. This heritage has been extended with the comparatively …
Fibroblast growth factor 21: a versatile regulator of metabolic homeostasis
LD BonDurant, MJ Potthoff - Annual review of nutrition, 2018 - annualreviews.org
Fibroblast growth factor 21 (FGF21) is an endocrine hormone derived from the liver that
exerts pleiotropic effects on the body to maintain overall metabolic homeostasis. During the …
exerts pleiotropic effects on the body to maintain overall metabolic homeostasis. During the …