The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

POU domain factors are transcriptional regulators characterized by a highly conserved DNA-
binding domain referred to as the POU domain. The structure of the POU domain has been …

Although much progress has been made in understanding the molecular mechanisms
regulating left-right asymmetry, the final events of asymmetric organ morphogenesis remain …

Three major PITX2 isoforms are differentially expressed in human, mice, zebrafish, chick,
and frog tissues. To demonstrate differential regulation of gene expression by these isoforms …

▪ Abstract During the development of the pituitary gland, distinct hormone-producing cell
types arise from a common population of ectodermal progenitors, providing an instructive …

In the sea urchin embryo, the large micromeres and their progeny function as a critical
signaling center and execute a complex morphogenetic program. We have identified a new …

Axenfeld–Rieger (AR) malformations are autosomal dominant developmental defects of the
anterior segment of the eye, and often result in glaucomatous blindness. AR malformations …

The mouse incisor is a remarkable tooth that grows throughout the animal's lifetime. This
continuous renewal is fueled by adult epithelial stem cells that give rise to ameloblasts …

Craniofacial development is a multistep and intricate process initially involving a number of
inductive interactions that control neural and neural crest development, which are followed …

The autosomal dominant disorders iris hypolasia (IH), iridogoniodysgenesis syndrome
(IGDS) and Axenfeld–Rieger syndrome (ARS) are characterized by maldevelopment of the …