The ability to monitor changes in the ionic composition of the extracellular environment is a
crucial feature that has evolved in all living organisms. The cloning and characterization of …

The calcium-sensing receptor (CaSR) plays a critical role in sensing extracellular calcium
(Ca2+) and signaling to maintain Ca2+ homeostasis. In the parathyroid, the CaSR regulates …

The calcium-sensing receptor (CaSR) was cloned over 20 years ago and functionally
demonstrated to regulate circulating levels of parathyroid hormone by maintaining …

Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Although
hyperglycaemia has been determined as the most important risk factor, hypoxia also plays a …

Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations of PKD1 or
PKD2 genes, is characterized by development and growth of cysts causing progressive …

Clinical and fundamental research suggest that altered calcium and cAMP signaling might
be the most proximal events in ADPKD pathogenesis. Cells from ADPKD cysts have a …

Acmella oleracea is well recognized in Brazilian traditional medicine as diuretic, although
few scientific data have been published to support this effect. Aim of this study was to …

Traumatic joint injuries produce osteoarthritic cartilage manifesting accelerated chondrocyte
terminal differentiation and matrix degradation via unknown cellular and molecular …

High concentrations of urinary calcium counteract vasopressin action via the activation of the
calcium-sensing receptor (CaSR) that is expressed in the luminal membrane of collecting …

Vasopressin (AVP) increases water permeability in the renal collecting duct through the
regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and …