Insulin resistance is common in the general population and tends to cluster with glucose
intolerance, dyslipidaemia and high blood pressure. The importance of the insulin-resistant …

Genetic Basis of Type 2 Diabetes Mellitus: Impaired Insulin Secretion versus Impaired Insulin
Sensitivity | Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement Oxford …

The increased prevalence of non-insulin-dependent diabetes mellitus (NIDDM) among
women with polycystic ovary syndrome (PCOS) has been ascribed to the insulin resistance …

Context: Epidemiological data indicate that reduced sleep duration is associated with
increased incidence of type-2 diabetes. Objective: The aim of the study was to test the …

The pivotal role in vivo of insulin is to control fuel homeostasis. Insulin exerts its effect on
three main target tissues: liver, fat and skeletal muscle. Resistance to the normal action of …

During the past half‐century, there has been a dramatic increase in the incidence of obesity,
insulin resistance and type 2 diabetes. A hallmark feature of these conditions is impaired …

We investigated the response of the glucose transport system to insulin, in the presence of
ambient glucose concentrations, in isolated skeletal muscle from seven patients with non …

First-degree relatives of NIDDM patients have an∼ 40% lifetime risk of developing diabetes,
and insulin resistance is the best predictor. However, insulin resistance is altered by many …

Objective.—To test the hypothesis that insulin resistance precedes impaired insulin
secretion in individuals genetically predisposed to non-insulin-dependent diabetes mellitus …

BACKGROUND: Insulin sensitivity and insulin secretion are traits that are both genetically
and environmentally determined. AIM: The aim of this study was to describe the distribution …