[HTML][HTML] Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants
Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …
Applications of nanotechnology for immunology
DM Smith, JK Simon, JR Baker Jr - Nature Reviews Immunology, 2013 - nature.com
Nanotechnology uses the unique properties of objects that function as a unit within the
overall size range of 1–1,000 nanometres. The engineering of nanostructure materials …
overall size range of 1–1,000 nanometres. The engineering of nanostructure materials …
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines
Lipid nanoparticle (LNP)-formulated messenger RNA (mRNA) vaccineare a promising
platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV …
platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV …
Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: a double-blind, randomised, phase 1 trial
R Ella, KM Vadrevu, H Jogdand, S Prasad… - The Lancet Infectious …, 2021 - thelancet.com
Background To mitigate the effects of COVID-19, a vaccine is urgently needed. BBV152 is a
whole-virion inactivated SARS-CoV-2 vaccine formulated with a toll-like receptor 7/8 agonist …
whole-virion inactivated SARS-CoV-2 vaccine formulated with a toll-like receptor 7/8 agonist …
Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: interim results from a double-blind, randomised, multicentre, phase 2 trial, and 3-month …
R Ella, S Reddy, H Jogdand, V Sarangi… - The Lancet Infectious …, 2021 - thelancet.com
Background BBV152 is a whole-virion inactivated SARS-CoV-2 vaccine (3 μg or 6 μg)
formulated with a toll-like receptor 7/8 agonist molecule (IMDG) adsorbed to alum (Algel) …
formulated with a toll-like receptor 7/8 agonist molecule (IMDG) adsorbed to alum (Algel) …
Nanomaterials and their impact on the immune system
Nanomaterials have been the focus of intensive development and research in the medical
and industrial sectors over the past several decades. Some studies have found that these …
and industrial sectors over the past several decades. Some studies have found that these …
The use of Toll-like receptor 7/8 agonists as vaccine adjuvants
JP Vasilakos, MA Tomai - Expert review of vaccines, 2013 - Taylor & Francis
Small molecule Toll-like receptor (TLR) 7/8 agonists have demonstrated potential as vaccine
adjuvants, since they directly activate APCs and can enhance both humoral and cellular …
adjuvants, since they directly activate APCs and can enhance both humoral and cellular …
A review on SARS-CoV-2-induced neuroinflammation, neurodevelopmental complications, and recent updates on the vaccine development
M Karnik, NM Beeraka, CA Uthaiah, SM Nataraj… - Molecular …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a devastating viral infection caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The incidence and …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The incidence and …
Safety and immunogenicity clinical trial of an inactivated SARS-CoV-2 vaccine, BBV152 (a phase 2, double-blind, randomised controlled trial) and the persistence of …
R Ella, S Reddy, H Jogdand, V Sarangi, B Ganneru… - medRxiv, 2020 - medrxiv.org
Background BBV152 is a whole-virion inactivated SARS-CoV-2 vaccine (3 µg or 6 µg)
formulated with a Toll-like receptor 7/8 agonist molecule adsorbed to alum (Algel-IMDG) …
formulated with a Toll-like receptor 7/8 agonist molecule adsorbed to alum (Algel-IMDG) …
Polyphosphazene immunoadjuvants: Historical perspective and recent advances
AK Andrianov, R Langer - Journal of Controlled Release, 2021 - Elsevier
The development of successful vaccines has been increasingly reliant on the use of
immunoadjuvants-additives, which can enhance and modulate immune responses to …
immunoadjuvants-additives, which can enhance and modulate immune responses to …