Engineering a biomimetic three-dimensional nanostructured bone model for breast cancer bone metastasis study

W Zhu, M Wang, Y Fu, NJ Castro, SW Fu, LG Zhang - Acta biomaterialia, 2015 - Elsevier
Traditional breast cancer (BrCa) bone metastasis models contain many limitations with
regards to controllability, reproducibility and flexibility of design. In this study, a novel …

Enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation in electrospun constructs with carbon nanomaterials

B Holmes, X Fang, A Zarate, M Keidar, LG Zhang - Carbon, 2016 - Elsevier
Cartilage as a tissue in the body possesses a low regenerative capacity and is extremely
difficult to repair. Today, treatment of cartilage injury, degeneration and defects presents …

Biomimetic biphasic 3‐D nanocomposite scaffold for osteochondral regeneration

NJ Castro, CM O'Brien, LG Zhang - AIChE Journal, 2014 - Wiley Online Library
Scaffold‐based interfacial tissue engineering aims to not only provide the structural and
mechanical framework for cellular growth and tissue regeneration, but also direct cell …

Biomimetic biphasic 3D nanocomposite scaffold for osteochondral regeneration

NJ Castro, CM O'brien, LG Zhang - US Patent 10,406,261, 2019 - Google Patents
The invention describes methods for producing a biphasic nanocomposite scaffold
comprising custom polymer-based core-shelled nanospheres by the physical and chemical …

Nanopartículas de colagénio para terapias da cartilagem baseadas em recursos marinhos

FHOMP Costa - 2019 - search.proquest.com
A cartilagem articular é constituída por matriz extracelular e condrócitos, sendo ancorada no
osso subcondral. O seu principal problema é a limitada capacidade de reparação …

[图书][B] Synthesis and Manufacture of 3D Nanocomposite Scaffolds for Osteochondral Regeneration via Table-top 3D Printing

NJ Castro - 2016 - search.proquest.com
Osteoarthritis and degenerative joint disease are largely intractable and difficult to address
with current traditional surgical methods due to the poor inherent regenerative capacity …

Advanced Fabrication Techniques for Precisely Controlled Micro and Nano Scale Environments for Complex Tissue Regeneration and Biomedical Applications

B Holmes - 2015 - search.proquest.com
As modern medicine advances, it is still very challenging to cure joint defects due to their
poor inherent regenerative capacity, complex stratified architecture, and disparate …