Sympathetic transduction in humans: recent advances and methodological considerations

BE Young, JL Greaney, DM Keller… - American Journal of …, 2021 - journals.physiology.org
Ever since their origin more than one half-century ago, microneurographic recordings of
sympathetic nerve activity have significantly advanced our understanding of the generation …

Sex differences in vascular transduction of sympathetic nerve activity

SL Hissen, CE Taylor - Clinical Autonomic Research, 2020 - Springer
Purpose Sympathetic vasoconstriction plays a major role in the beat-to-beat control of blood
pressure. To be effective and thus avoid dangerously high or low blood pressures, this …

Elevated muscle sympathetic nerve activity contributes to central artery stiffness in young and middle-age/older adults

SW Holwerda, RE Luehrs, L DuBose, MT Collins… - …, 2019 - Am Heart Assoc
Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular
smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether …

Exaggerated vasoconstriction to spontaneous bursts of muscle sympathetic nerve activity in healthy young black men

JR Vranish, SW Holwerda, BE Young, DP Credeur… - …, 2018 - Am Heart Assoc
Blacks have the highest prevalence of hypertension, putting them at greater risk of
cardiovascular disease and death. Previous studies have reported that, relative to whites …

Age-and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans

AW D'Souza, SL Hissen, K Manabe… - American Journal …, 2023 - journals.physiology.org
Bursts of muscle sympathetic nerve activity (MSNA) and the ensuing vasoconstriction are
pivotal determinants of beat-by-beat blood pressure regulation. Although age and sex …

Augmented pressor and sympathetic responses to skeletal muscle metaboreflex activation in type 2 diabetes patients

SW Holwerda, RM Restaino… - American Journal …, 2016 - journals.physiology.org
Previous studies have reported exaggerated increases in arterial blood pressure during
exercise in type 2 diabetes (T2D) patients. However, little is known regarding the underlying …

Fifty years of microneurography: learning the language of the peripheral sympathetic nervous system in humans

JK Shoemaker, SA Klassen… - Journal of …, 2018 - journals.physiology.org
As a primary component of homeostasis, the sympathetic nervous system enables rapid
adjustments to stress through its ability to communicate messages among organs and cause …

Sex differences in dynamic blood pressure regulation: beat-by-beat responses to muscle sympathetic nerve activity

Y Coovadia, TE Adler, CD Steinback… - American Journal …, 2020 - journals.physiology.org
It has been suggested that sex differences in acute blood pressure fluctuations occur during
the periods of time between bursts of muscle sympathetic nerve activity. Therefore, we tested …

Acute intermittent hypercapnic hypoxia and sympathetic neurovascular transduction in men

TJR Stuckless, TD Vermeulen, CV Brown… - The Journal of …, 2020 - Wiley Online Library
Key points Intermittent hypoxia leads to long‐lasting increases in muscle sympathetic nerve
activity and blood pressure, contributing to increased risk for hypertension in obstructive …

Relation between resting sympathetic outflow and vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults

AT Robinson, MC Babcock, JC Watso… - American Journal …, 2019 - journals.physiology.org
Previous studies have demonstrated an inverse relation between resting muscle
sympathetic nerve activity (MSNA) and vasoconstrictor responsiveness (ie, sympathetic …