Lysosomal membrane permeabilization and cell death
F Wang, R Gómez‐Sintes, P Boya - Traffic, 2018 - Wiley Online Library
Lysosomes are membrane‐enclosed organelles that mediate the intracellular degradation
of macromolecules. They play an essential role in calcium regulation and have emerged as …
of macromolecules. They play an essential role in calcium regulation and have emerged as …
[HTML][HTML] Pore-forming toxins: ancient, but never really out of fashion
MD Peraro, FG Van Der Goot - Nature reviews microbiology, 2016 - nature.com
Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …
[HTML][HTML] Whole genome analysis of a schistosomiasis-transmitting freshwater snail
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma
mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global …
mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global …
[HTML][HTML] Why do we study animal toxins?
Y Zhang - Zoological research, 2015 - ncbi.nlm.nih.gov
Venom (toxins) is an important trait evolved along the evolutionary tree of animals. Our
knowledges on venoms, such as their origins and loss, the biological relevance and the …
knowledges on venoms, such as their origins and loss, the biological relevance and the …
[HTML][HTML] Lysosomal cell death mechanisms in aging
R Gómez-Sintes, MD Ledesma, P Boya - Ageing research reviews, 2016 - Elsevier
Lysosomes are degradative organelles essential for cell homeostasis that regulate a variety
of processes, from calcium signaling and nutrient responses to autophagic degradation of …
of processes, from calcium signaling and nutrient responses to autophagic degradation of …
Lysosomal membrane permeabilization as a cell death mechanism in cancer cells
A Serrano-Puebla, P Boya - Biochemical Society Transactions, 2018 - portlandpress.com
Lysosomes are acidic organelles that contain hydrolytic enzymes that mediate the
intracellular degradation of macromolecules. Damage of these organelles often results in …
intracellular degradation of macromolecules. Damage of these organelles often results in …
[HTML][HTML] Bacterial exotoxins and the inflammasome
AJ Greaney, SH Leppla, M Moayeri - Frontiers in immunology, 2015 - frontiersin.org
The inflammasomes are intracellular protein complexes that play an important role in innate
immune sensing. Activation of inflammasomes leads to activation of caspase-1 and …
immune sensing. Activation of inflammasomes leads to activation of caspase-1 and …
[HTML][HTML] Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis
X Huang, Y Feng, G Xiong, S Whyte, J Duan, Y Yang… - Cell & bioscience, 2019 - Springer
Pyroptosis, a type of programmed cell death that along with inflammation, is mainly
regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1 …
regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1 …
[HTML][HTML] Animal secretory endolysosome channel discovery
Y Zhang, QQ Wang, Z Zhao, CJ Deng - Zoological research, 2021 - ncbi.nlm.nih.gov
Secretory pore-forming proteins (PFPs) have been identified in organisms from all kingdoms
of life. Our studies with the toad species Bombina maxima found an interaction network …
of life. Our studies with the toad species Bombina maxima found an interaction network …
[HTML][HTML] The natterin proteins diversity: A review on phylogeny, structure, and immune function
Since the first record of the five founder members of the group of Natterin proteins in the
venom of the medically significant fish Thalassophryne nattereri, new sequences have been …
venom of the medically significant fish Thalassophryne nattereri, new sequences have been …