Lysosomes are membrane‐enclosed organelles that mediate the intracellular degradation
of macromolecules. They play an essential role in calcium regulation and have emerged as …

Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma
mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global …

Venom (toxins) is an important trait evolved along the evolutionary tree of animals. Our
knowledges on venoms, such as their origins and loss, the biological relevance and the …

Lysosomes are degradative organelles essential for cell homeostasis that regulate a variety
of processes, from calcium signaling and nutrient responses to autophagic degradation of …

Lysosomes are acidic organelles that contain hydrolytic enzymes that mediate the
intracellular degradation of macromolecules. Damage of these organelles often results in …

The inflammasomes are intracellular protein complexes that play an important role in innate
immune sensing. Activation of inflammasomes leads to activation of caspase-1 and …

Pyroptosis, a type of programmed cell death that along with inflammation, is mainly
regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1 …

Secretory pore-forming proteins (PFPs) have been identified in organisms from all kingdoms
of life. Our studies with the toad species Bombina maxima found an interaction network …

Since the first record of the five founder members of the group of Natterin proteins in the
venom of the medically significant fish Thalassophryne nattereri, new sequences have been …