More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

INTRODUCTION Histone modification activity of the polycomb repressive complexes 1 and
2 (PRC1 and PRC2) is critical for the establishment and maintenance of gene expression …

The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-
2. However, mice with a T-cell-specific deletion of SHP-2 do not have improved antitumor …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …

Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is
believed to ensure a condensed and transcriptionally inert chromatin conformation …

Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of
time. This state, which is reversible, has long been viewed as dormant and with minimal …

The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …