Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …

Myasthenia Gravis (MG) is a paradigm of organ-specific autoimmune disease (AID). It is
mediated by antibodies that target the neuromuscular junction. The purpose of this review is …

The interleukin (IL)‐12/IL‐23‐mediated Th1/Th17 signaling pathway has been associated
with the etiopathogenesis of primary biliary cirrhosis (PBC). To address the cytokine …

Genome-wide association studies (GWASs) have been a significant technological advance
in our ability to evaluate the genetic architecture of complex diseases such as primary biliary …

Systemic sclerosis (SSc) is a rare connective tissue disease of unknown etiology
characterized by chronic inflammation and fibrosis of the skin, vascular abnormalities, and …

IL-12 is a pro-inflammatory cytokine that induces the production of interferon-γ (IFNγ) and
favours the differentiation of T helper 1 (Th1) cells. In the presence of IL-12 human Treg cells …

Abstract Interleukin (IL)-12 family cytokines are heterodimers of an α-chain (p19, p28 and
p35) and a β-chain (p40 and Ebi3), present as IL-12 (p35/p40), IL-23 (p19/p40), IL-27 …

Systemic sclerosis (SSc) is connective tissue disorder in which fibrosis of the skin and
internal organs is the main hallmark. Despite the difficulties of studying a complex disease …

The objective of this study was to determine the ameliorative effects of Antrodia cinnamomea
polysaccharide (ACPS) against cyclophosphamide (CTX)-induced immunosuppression in …

Primary biliary cirrhosis (PBC) is considered a model autoimmune disease, with the most
highly directed and specific autoantibody in both murine and human autoimmunity, the anti …