Advances in extracellular vesicle nanotechnology for precision theranostics

Q Wu, S Fu, H Xiao, J Du, F Cheng, S Wan… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) have increasingly been recognized as important cell surrogates
influencing many pathophysiological processes, including cellular homeostasis, cancer …

The CRISPR/Cas9 system delivered by extracellular vesicles

X Zhu, M Gao, Y Yang, W Li, J Bao, Y Li - Pharmaceutics, 2023 - mdpi.com
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) systems can precisely manipulate DNA sequences to change the …

Engineered extracellular vesicle-delivered CRISPR/cas9 for radiotherapy sensitization of glioblastoma

X Liu, Z Cao, W Wang, C Zou, Y Wang, L Pan, B Jia… - ACS …, 2023 - ACS Publications
Radiotherapy is a mainstay of glioblastoma (GBM) treatment; however, the development of
therapeutic resistance has hampered the efficacy of radiotherapy, suggesting that additional …

Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing

JA Whitley, H Cai - Journal of Extracellular Vesicles, 2023 - Wiley Online Library
Clustered regularly interspaced palindromic repeats (CRISPR) is a gene editing tool with
tremendous therapeutic potential. Recently, ribonucleoprotein (RNP) complex‐based …

Advances in biomaterials for the treatment of retinoblastoma

W Farhat, V Yeung, A Ross, F Kahale, N Boychev… - Biomaterials …, 2022 - pubs.rsc.org
Retinoblastoma is the most common primary intraocular malignancy in children. Although
traditional chemotherapy has shown some success in retinoblastoma management, there …

New therapeutics for extracellular vesicles: delivering CRISPR for cancer treatment

B Yan, Y Liang - International Journal of Molecular Sciences, 2022 - mdpi.com
Cancers are defined by genetic defects, which underlines the prospect of using gene
therapy in patient care. During the past decade, CRISPR technology has rapidly evolved …

Advances in the therapeutic effects of apoptotic bodies on systemic diseases

X Li, Y Liu, X Liu, J Du, UK Bhawal, J Xu… - International Journal of …, 2022 - mdpi.com
Apoptosis plays an important role in development and in the maintenance of homeostasis.
Apoptotic bodies (ApoBDs) are specifically generated from apoptotic cells and can contain a …

Current and prospective strategies for advancing the targeted delivery of CRISPR/Cas system via extracellular vesicles

X Huang, A Li, P Xu, Y Yu, S Li, L Hu… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) have emerged as a promising platform for gene delivery owing
to their natural properties and phenomenal functions, being able to circumvent the …

Engineered extracellular vesicle‐delivered CRISPR/CasRx as a novel RNA editing tool

T Li, L Zhang, T Lu, T Zhu, C Feng, N Gao… - Advanced …, 2023 - Wiley Online Library
Engineered extracellular vesicles (EVs) are considered excellent delivery vehicles for a
variety of therapeutic agents, including nucleic acids, proteins, drugs, and nanomaterials …

[HTML][HTML] Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

S Nair, V Ormazabal, F Carrion, A Handberg… - Clinical …, 2023 - portlandpress.com
Extracellular vesicles (EVs) are critical mediators of cell communication, playing important
roles in regulating molecular cross-talk between different metabolic tissues and influencing …