Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations

AI Ritchie, JA Wedzicha - Clinics in chest medicine, 2020 - chestmed.theclinics.com
Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are episodes of
symptom worsening 1 that have significant adverse consequences for patients. 2 The …

Diagnosis and outpatient management of chronic obstructive pulmonary disease: a review

CM Riley, FC Sciurba - Jama, 2019 - jamanetwork.com
Importance There are 30 million adults (12%) in the United States who have chronic
obstructive pulmonary disease (COPD). Chronic obstructive pulmonary disease accounts for …

COPD–do the right thing

H Sandelowsky, UM Weinreich, BB Aarli, J Sundh… - BMC family …, 2021 - Springer
A gap exists between guidelines and real-world clinical practice for the management and
treatment of chronic obstructive pulmonary disease (COPD). Although this has narrowed in …

Prognostic risk factors for moderate-to-severe exacerbations in patients with chronic obstructive pulmonary disease: a systematic literature review

JR Hurst, MLK Han, B Singh, S Sharma, G Kaur… - Respiratory …, 2022 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity
and mortality worldwide. COPD exacerbations are associated with a worsening of lung …

Frequency and severity of exacerbations of COPD associated with future risk of exacerbations and mortality: a UK routine health care data study

H Whittaker, A Rubino, H Müllerová… - … Journal of Chronic …, 2022 - Taylor & Francis
Background Studies have shown that chronic obstructive pulmonary disease (COPD)
exacerbation events are related to future events; however, previous literature typically …

[HTML][HTML] Understanding the impact of chronic obstructive pulmonary disease exacerbations on patient health and quality of life

JR Hurst, N Skolnik, GJ Hansen, A Anzueto… - European journal of …, 2020 - Elsevier
Exacerbations of chronic obstructive pulmonary disease (COPD) represent a significant
clinical problem, and are associated with decreased lung function, worsening quality of life …

Home high-flow nasal cannula oxygen therapy for stable hypercapnic COPD: a randomized clinical trial

K Nagata, T Horie, N Chohnabayashi… - American Journal of …, 2022 - atsjournals.org
Rationale: The long-term effects of using a high-flow nasal cannula for chronic hypercapnic
respiratory failure caused by chronic obstructive pulmonary disease remain unclear …

ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations

AG Mathioudakis, F Abroug, A Agusti… - European …, 2022 - Eur Respiratory Soc
Clinical trials evaluating the management of acute exacerbations of COPD assess
heterogeneous outcomes, often omitting those that are clinically relevant or more important …

Identifying clinically important COPD sub-types using data-driven approaches in primary care population based electronic health records

M Pikoula, JK Quint, F Nissen, H Hemingway… - BMC medical informatics …, 2019 - Springer
Background COPD is a highly heterogeneous disease composed of different phenotypes
with different aetiological and prognostic profiles and current classification systems do not …

How inhaled corticosteroids target inflammation in COPD

S Lea, A Higham, A Beech… - European Respiratory …, 2023 - Eur Respiratory Soc
Inhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the
treatment of COPD. COPD has been previously described as a “corticosteroid-resistant” …