The contribution of the peripheral immune system to neurodegeneration
F Berriat, CS Lobsiger, S Boillée - Nature Neuroscience, 2023 - nature.com
Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …
react to neurodegeneration, but other immune cell types are also able to react to pathology …
Decoding ALS: from genes to mechanism
Amyotrophic lateral sclerosis (ALS) is a progressive and uniformly fatal neurodegenerative
disease. A plethora of genetic factors have been identified that drive the degeneration of …
disease. A plethora of genetic factors have been identified that drive the degeneration of …
Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes
J Humphrey, S Venkatesh, R Hasan, JT Herb… - Nature …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a progressively fatal neurodegenerative disease
affecting motor neurons in the brain and spinal cord. In this study, we investigated gene …
affecting motor neurons in the brain and spinal cord. In this study, we investigated gene …
Efficacy assessment of biosynthesized copper oxide nanoparticles (CuO-NPs) on stored grain insects and their impacts on morphological and physiological traits of …
Simple Summary In the current study, copper oxide nanoparticles (CuO-NPs) were
successfully formed through the reduction of CuSO4· 5H2O by the activity of Aspergillus …
successfully formed through the reduction of CuSO4· 5H2O by the activity of Aspergillus …
How neuroinflammation contributes to neurodegeneration
RM Ransohoff - Science, 2016 - science.org
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …
[PDF][PDF] Astrocyte-immune cell interactions in physiology and pathology
Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …
system (CNS) function. Here, we review the varied functions of astrocytes and how these …
Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons
Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease involving loss
of motor neurons (MNs) and muscle atrophy, still has no effective treatment, despite much …
of motor neurons (MNs) and muscle atrophy, still has no effective treatment, despite much …
Non-neuronal cells in amyotrophic lateral sclerosis—from pathogenesis to biomarkers
The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …
Astrocyte barriers to neurotoxic inflammation
MV Sofroniew - Nature Reviews Neuroscience, 2015 - nature.com
Astrocytes form borders (glia limitans) that separate neural from non-neural tissue along
perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function …
perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function …
Innate immune activation in neurodegenerative disease
The triggering of innate immune mechanisms is emerging as a crucial component of major
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …