Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often
beneficial to energy expenditure; however, increased circulating levels of BCAA are linked …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity,
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …

Adipokines secreted from white adipose tissue play a role in metabolic crosstalk and
homeostasis, whereas the brown adipose secretome is less explored. We performed high …

The location and identity of phospholipids (PLs) within tissues can serve as diagnostic
markers for tissue types or diseases. Whereas mass spectrometry imaging (MSI) has …

The mainstream of lipidomics involves mass spectrometry-based, systematic, and large-
scale studies of the structure, composition, and quantity of lipids in biological systems such …

Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which
brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner …

Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic
health in diverse species. However, whether DR in mammals is still effective when applied …