That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Parkinson disease (PD) is a chronic, progressive neurological disease that is associated
with a loss of dopaminergic neurons in the substantia nigra pars compacta of the brain. The …

DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …

Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …

Loss-of-function mutations in DJ-1 are associated with autosomal recessive early onset
Parkinson's disease (PD), yet the underlying pathogenic mechanism remains elusive. Here …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …