Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal
transition (EMT) is the process in which cells lose epithelial integrity and become motile, a …

ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion
of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous …

Metabolic phenotyping involves the comprehensive analysis of biological fluids or tissue
samples. This analysis allows biochemical classification of a person's physiological or …

Background Prostate cancer tissues are inherently heterogeneous, which presents a
challenge for metabolic profiling using traditional bulk analysis methods that produce an …

The malignant transformation of cells requires adaptations across multiple metabolic
processes to satisfy the energy required for their increased rate of proliferation …

Cancer is a devastating disease that alters the metabolism of a cell and the surrounding
milieu. Metabolomics is a growing and powerful technology capable of detecting hundreds …

Prostate cancer is a highly prevalent tumor affecting millions of men worldwide, but poor
understanding of its pathogenesis has limited effective clinical management of patients. In …

Separating indolent from aggressive prostate cancer is an important clinical challenge for
identifying patients eligible for active surveillance, thereby reducing the risk of overtreatment …

Prostate cancer (PCa) is the second most diagnosed cancer in men worldwide. For its
screening, serum prostate specific antigen (PSA) test has been largely performed over the …

Background The aims of this study were to characterize the metabolite profiles of triple
negative breast cancer (TNBC) and to investigate the metabolite profiles associated with …