Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

Several polycations possessing substantial buffering capacity below physiological pH, such
as lipopolyamines and polyamidoamine polymers, are efficient transfection agents per se …

Lipid‐based nanoparticles have emerged as a clinically viable platform technology to
deliver nucleic acids for a wide range of healthcare applications. Within this scope, one of …

Background The relatively high transfection efficiency of polyethylenimine (PEI) vectors has
been hypothesized to be due to their ability to avoid trafficking to degradative lysosomes …

Several non-permanent polycations possessing substantial buffering capacity below
physiological pH, such as lipopolyamines and polyethylenimines, are efficient transfection …

A two-dimensional columnar phase in mixtures of DNA complexed with cationic liposomes
has been found in the lipid composition regime known to be significantly more efficient at …

Liposomes have a wide array of uses that have been continuously expanded and improved
upon since first being observed to self‐assemble into vesicular structures. These …

The mechanism whereby cationic lipids destabilize cell membranes to facilitate the
intracellular delivery of macromolecules such as plasmid DNA or antisense oligonucleotides …

The specific properties of fluorocarbons, exceptional chemical and biological inertness, high
gas-dissolving capacity, low surface tension, excellent spreading characteristics and high …