The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

Nephrons possess a segmental organization where each segment is specialized for the
secretion and reabsorption of particular solutes. The developmental control of nephron …

Normal tables of development are essential for studies of embryogenesis, serving as an
important resource for model organisms, including the frog Xenopus laevis. Xenopus has …

Kidney function depends on the nephron, which comprises a blood filter, a tubule that is
subdivided into functionally distinct segments, and a collecting duct. How these regions …

Podocytes are specialized cells of the kidney that form the blood filtration barrier in the
kidney glomerulus. The barrier function of podocytes depends upon the development of …

The RNA-binding protein Bicaudal C is an important regulator of embryonic development in
C. elegans, Drosophila and Xenopus. In mouse, bicaudal C (Bicc1) mutants are …

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
at the post-transcriptional level. They are involved in diverse biological processes, such as …

Over the past years, the Xenopus embryo has emerged as an incredibly useful model
organism for studying the formation and function of cilia and ciliated epithelia in vivo. This …

The nephron is the basic structural and functional unit of the vertebrate kidney. To ensure
kidney functions, the nephrons possess a highly segmental organization where each …

Odd-skipped family of proteins (Odd in Drosophila and Osr in vertebrates) are evolutionarily
conserved zinc finger transcription factors. Two Osr genes are present in mammalian …