Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

B Li, J Jiang, YG Assaraf, H Xiao, ZS Chen… - Drug resistance …, 2020 - Elsevier
Despite the development of targeted therapy, drug resistance remains a primary hindrance
to curative treatment of various cancers. Among several novel approaches to overcome drug …

Targeting RNA N6-methyladenosine to synergize with immune checkpoint therapy

X Zhou, C Li, T Chen, W Li, X Wang, Q Yang - Molecular Cancer, 2023 - Springer
Cancer immunotherapy, especially immune checkpoint therapy, has revolutionized
therapeutic options by reactivating the host immune system. However, the efficacy varies …

The m6A RNA demethylase ALKBH5 promotes radioresistance and invasion capability of glioma stem cells

A Kowalski-Chauvel, MG Lacore, F Arnauduc… - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma stem cells (GBMSCs), which are particularly radio-resistant
and invasive, are responsible for the high recurrence of glioblastoma (GBM). Therefore …

SDTNBI: an integrated network and chemoinformatics tool for systematic prediction of drug–target interactions and drug repositioning

Z Wu, F Cheng, J Li, W Li, G Liu… - Briefings in …, 2017 - academic.oup.com
Computational prediction of drug–target interactions (DTIs) and drug repositioning provides
a low-cost and high-efficiency approach for drug discovery and development. The traditional …

The hippocampal FTO-BDNF-TrkB pathway is required for novel object recognition memory reconsolidation in mice

R Chang, S Zhu, J Peng, Z Lang, X Zhou, H Liao… - Translational …, 2023 - nature.com
Memory reconsolidation refers to the process by which the consolidated memory was
restored after reactivation (RA). Memory trace becomes labile after reactivation and …

The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues

AM Añazco-Guenkova, B Miguel-López… - NAR …, 2024 - academic.oup.com
Recent advancements have illuminated the critical role of RNA modifications in post-
transcriptional regulation, shaping the landscape of gene expression. This review explores …

[HTML][HTML] N6-methyladenosine (m6A) methylation in kidney diseases: Mechanisms and therapeutic potential

Y Sun, D Jin, Z Zhang, H Ji, X An, Y Zhang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract The N6-methyladenosine (m6A) modification is regulated by methylases, commonly
referred to as “writers,” and demethylases, known as “erasers,” leading to a dynamic and …

Bioelectric pharmacology of cancer: a systematic review of ion channel drugs affecting the cancer phenotype

K Kofman, M Levin - Progress in Biophysics and Molecular Biology, 2024 - Elsevier
Cancer is a pernicious and pressing medical problem; moreover, it is a failure of
multicellular morphogenesis that sheds much light on evolutionary developmental biology …

The potential preventive and therapeutic roles of NSAIDs in prostate cancer

H Maghsoudi, F Sheikhnia, P Sitarek, N Hajmalek… - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer is a serious health problem for men around the world, and
it is often caused by inflammation in the prostate gland. The authors of this article explore …

5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy

K Bishayee, AR Khuda-Bukhsh - Acta Biochim Biophys Sin, 2013 - academic.oup.com
Leukotrienes are the bioactive group of fatty acids and major constituents of arachidonic
acid metabolism molded by the catalytic activity of 5-lipoxygenase (5-LOX). Evidence is …