Ferroptosis is defined as an iron-dependent, non-apoptotic cell death pathway, with specific
morphological phenotypes and biochemical changes. There is a growing realization that …

Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly
conserved among eukaryotes) to itself or to other proteins through differential use of …

Background The catenin beta 1 gene (CTNNB1) plays a crucial role in the malignant
progression of various cancers. Recent studies have suggested that CTNNB1 …

With the recognition in the early 1960s that histones can be post-translationally modified, the
list of different post-translational modifications of histones and their biological consequences …

Ubiquitin C‑terminal hydrolase‑L1 (UCH‑L1), a member of the lesser‑known
deubiquitinating enzyme family, has deubiquitinase and ubiquitin (Ub) ligase activity and the …

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), also known as Parkinson's disease
protein 5, is a highly expressed protein in the brain. It plays an important role in the ubiquitin …

Background To date, the pathogenesis of Alzheimer's disease is still not fully elucidated.
Much evidence suggests that Ferroptosis plays a crucial role in the pathogenesis of AD, but …

Epigenetic regulation is an important layer of transcriptional control with the particularity to
affect the broad spectrum of genome. Over the years, largely due to the substantial number …

The process of ubiquitination and deubiquitination is widely present in the human body's
protein reactions and plays versatile roles in multiple diseases. Deubiquitinating enzymes …

Simple Summary Clinical and molecular advances have improved knowledge and treatment
prospects for cancer, yet hepatocellular carcinoma (HCC), the most common form of liver …