Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …

Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …

T cells, the critical immune cells of the adaptive immune system, are often dysfunctional in
Alzheimer's disease (AD) and are involved in AD pathology. Reports highlight …

Central response to insulin is suspected to be defective in Alzheimer's disease. As most
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …

Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-
associated insulin resistance remains unknown. Here, we identify membrane-bound matrix …

The molecular mechanism underlying pancreatic ductal adenocarcinoma (PDAC)
malignancy remains unclear. Here, we characterize a long intergenic non-coding RNA …

Background The protease BACE1 is a major drug target for Alzheimer's disease, but chronic
BACE1 inhibition is associated with non-progressive cognitive worsening that may be …

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …

Amyloid precursor protein (APP) is a transmembrane precursor protein that is widely
expressed in the central nervous system and peripheral tissues in the liver and pancreas …

Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that
have seen a rising prevalence worldwide. Recent studies have indicated a possible link …