Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease

OJ Olajide, ME Suvanto, CA Chapman - Biology Open, 2021 - journals.biologists.com
The entorhinal cortex (EC) is a vital component of the medial temporal lobe, and its
contributions to cognitive processes and memory formation are supported through its …

Inhibiting amyloid beta (1–42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex

OJ Olajide, C La Rue, A Bergdahl… - Frontiers in Aging …, 2022 - frontiersin.org
Increasing evidence suggests that mitochondrial dysfunction and aberrant release of
mitochondrial reactive oxygen species (ROS) play crucial roles in early synaptic …

Hippocampal degeneration and behavioral impairment during Alzheimer-like pathogenesis involves glutamate excitotoxicity

OJ Olajide, IT Gbadamosi, EO Yawson… - Journal of Molecular …, 2021 - Springer
The hallmarks of Alzheimer's disease (AD) pathology include senile plaques accumulation
and neurofibrillary tangles, which is thought to underlie synaptic failure. Recent evidence …

Sex‐specific metabolic signatures in methamphetamine addicts

Z Cheng, Y Peng, J Wen, W Chen, W Pan… - Addiction …, 2023 - Wiley Online Library
Methamphetamine (METH) is a commonly abused addictive psychostimulant, and METH‐
induced neurotoxic and behavioural deficits are in a sex‐specific manner. However, there is …

Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice

E de Oliveira Ferreira, JMP Gomes… - Behavioural …, 2023 - journals.lww.com
Autism spectrum disorder (ASD) describes a heterogeneous group of neurodevelopmental
conditions characterized by deficits in social communication and repetitive behaviors …

Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium

O Bamisi, AO Oluwalabani, TT Arogundade… - Neurotoxicology and …, 2024 - Elsevier
Although there have been reports indicating that Datura Stramonium (D. stramonium) may
induce anticholinergic and neuropsychiatry effects, the compound is still being used for …

[HTML][HTML] Inhibitory potentials of Cymbopogon citratus oil against aluminium-induced behavioral deficits and neuropathology in rats

GI Temitayo, B Olawande… - Anatomy & Cell …, 2020 - synapse.koreamed.org
Cymbopogon citratus is a tropical phytomedicinal plant that is widely known for its
hypoglycemic, hypolipidemic, anxiolytic, sedative, antioxidative and anti-inflammatory …

Neurobehavioral, neurochemical and synaptic plasticity perturbations during postnatal life of rats exposed to chloroquine in-utero

OJ Olajide, ZO Alliy, DO Ojo, OO Osinubi… - Neurotoxicology and …, 2021 - Elsevier
Despite reports that quinoline antimalarials including chloroquine (Chq) exhibit idiosyncratic
neuropsychiatric effects even at low doses, the drug continues to be in widespread use …

Fisetin potentiates anxiolysis in rat models of aluminium chloride-induced Alzheimer-like disease.

KK Obasi, GE Anyanwu - Journal of Krishna Institute of …, 2022 - search.ebscohost.com
Background: Alzheimer's disease is a chronic, irreversible neurological disease that affects
brain cells. Aim and Objectives: To investigate the remediatory benefits of fisetin against …

[PDF][PDF] Morphological Alterations and Neurochemical Responses in Lead (Pb) Intoxication in Rats: Prophylactic Potentials of Luteolin

LO Arietarhire, AI Ayuba, KST Keji-Taofik… - 2024 - preprints.org
The phenotypic manifestation of lead toxicity includes cognitive, learning, and memory
decline which is associated with neuronal injuries and death and been a major challenge in …