Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

Persistent pain, which is poorly treated and estimated to afflict one third of the world's
population, is largely mediated by the sensitization of nociceptive neurons. This sensitization …

Extrinsic signaling between diverse cell types is crucial for nervous system development.
Ligand binding is a key driver of developmental processes. Nevertheless, it remains a …

Through the generation of humanized FUS mice expressing full-length human FUS, we
identify that when expressed at near endogenous murine FUS levels, both wild-type and …

Injury-induced sensitization of nociceptors contributes to pain states and the development of
chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of …

Activation of the mechanistic target of rapamycin complex 1 (mTORC1) contributes to the
development of chronic pain. However, the specific mechanisms by which mTORC1 causes …

Translational control of gene expression has emerged as a key mechanism in regulating
different forms of long-lasting neuronal plasticity. Maladaptive plastic reorganization of …

Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in
response to pro-inflammatory signals. Comparatively little is known regarding the role of the …

Objectives: Osteoarthritis (OA) is known to be a slowly progressive disease that alters all
tissue compartments of the joint involved with a characteristic degradation of the cartilage …

Introduction: The mTOR pathway is involved in the regulation of a wide repertoire of cellular
functions in the brain and its dysregulation is emerging as a leitmotif in a large number of …