IgG subclasses and allotypes: from structure to effector functions
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
Mechanisms of autoantibody-induced pathology
RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
A copy number variation map of the human genome
M Zarrei, JR MacDonald, D Merico… - Nature reviews …, 2015 - nature.com
A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …
NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy
Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-
antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating …
antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating …
Pathogenesis of immune thrombocytopenia
S Audia, M Mahévas, M Samson, B Godeau… - Autoimmunity …, 2017 - Elsevier
Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell
response, notably supported by splenic T follicular helper cells, that stimulates the …
response, notably supported by splenic T follicular helper cells, that stimulates the …
Fcγ receptors and immunomodulatory antibodies in cancer
The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …
Emerging concepts in immune thrombocytopenia
M Swinkels, M Rijkers, J Voorberg… - Frontiers in …, 2018 - frontiersin.org
Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts
which presents with an increased bleeding risk. Several genetic risk factors (eg …
which presents with an increased bleeding risk. Several genetic risk factors (eg …
Expression, role, and regulation of neutrophil Fcγ receptors
Y Wang, F Jönsson - Frontiers in immunology, 2019 - frontiersin.org
Neutrophils are best known for their critical role in host defense, for which they utilize
multiple innate immune mechanisms, including microbe-associated pattern recognition …
multiple innate immune mechanisms, including microbe-associated pattern recognition …
The ligands for human IgG and their effector functions
Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …
and trigger effector functions through the interaction with Fc engaging molecules. The most …
[HTML][HTML] Mechanisms of action of CD20 antibodies
P Boross, JHW Leusen - American journal of cancer research, 2012 - ncbi.nlm.nih.gov
Therapeutic monoclonal antibodies (mAbs) that target the CD20 antigen on B cells are
successfully used in the clinic for the depletion of B cells to treat various forms of cancer and …
successfully used in the clinic for the depletion of B cells to treat various forms of cancer and …