IgG subclasses and allotypes: from structure to effector functions

G Vidarsson, G Dekkers, T Rispens - Frontiers in immunology, 2014 - frontiersin.org
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …

Mechanisms of autoantibody-induced pathology

RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

A copy number variation map of the human genome

M Zarrei, JR MacDonald, D Merico… - Nature reviews …, 2015 - nature.com
A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …

NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

W Wang, AK Erbe, JA Hank, ZS Morris… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-
antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating …

Pathogenesis of immune thrombocytopenia

S Audia, M Mahévas, M Samson, B Godeau… - Autoimmunity …, 2017 - Elsevier
Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell
response, notably supported by splenic T follicular helper cells, that stimulates the …

Fcγ receptors and immunomodulatory antibodies in cancer

F Galvez-Cancino, AP Simpson, C Costoya… - Nature Reviews …, 2024 - nature.com
The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …

Emerging concepts in immune thrombocytopenia

M Swinkels, M Rijkers, J Voorberg… - Frontiers in …, 2018 - frontiersin.org
Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts
which presents with an increased bleeding risk. Several genetic risk factors (eg …

Expression, role, and regulation of neutrophil Fcγ receptors

Y Wang, F Jönsson - Frontiers in immunology, 2019 - frontiersin.org
Neutrophils are best known for their critical role in host defense, for which they utilize
multiple innate immune mechanisms, including microbe-associated pattern recognition …

The ligands for human IgG and their effector functions

SW de Taeye, T Rispens, G Vidarsson - Antibodies, 2019 - mdpi.com
Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …

[HTML][HTML] Mechanisms of action of CD20 antibodies

P Boross, JHW Leusen - American journal of cancer research, 2012 - ncbi.nlm.nih.gov
Therapeutic monoclonal antibodies (mAbs) that target the CD20 antigen on B cells are
successfully used in the clinic for the depletion of B cells to treat various forms of cancer and …