Heparan sulfate proteoglycans
S Sarrazin, WC Lamanna… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …
where they interact with a plethora of ligands. Over the last decade, new insights have …
Exploring mechanisms of FGF signalling through the lens of structural biology
R Goetz, M Mohammadi - Nature reviews Molecular cell biology, 2013 - nature.com
Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing
and adult organism. The accumulated wealth of structural information on the FGF signalling …
and adult organism. The accumulated wealth of structural information on the FGF signalling …
Heparin–protein interactions
I Capila, RJ Linhardt - Angewandte Chemie International …, 2002 - Wiley Online Library
Heparin, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has
numerous important biological activities, associated with its interaction with diverse proteins …
numerous important biological activities, associated with its interaction with diverse proteins …
Heparan sulfate biosynthesis and sulfation profiles as modulators of cancer signalling and progression
Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …
The FGF metabolic axis
X Li - Frontiers of Medicine, 2019 - Springer
Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and
metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members …
metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members …
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
R Goetz, A Beenken, OA Ibrahimi… - … and cellular biology, 2007 - Taylor & Francis
Unique among fibroblast growth factors (FGFs), FGF19,-21, and-23 act in an endocrine
fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis …
fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis …
Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology
AA Belov, M Mohammadi - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Fibroblast growth factors (FGFs) signal in a paracrine or endocrine fashion to mediate a
myriad of biological activities, ranging from issuing developmental cues, maintaining tissue …
myriad of biological activities, ranging from issuing developmental cues, maintaining tissue …
Structural insights into biological roles of protein-glycosaminoglycan interactions
R Raman, V Sasisekharan, R Sasisekharan - Chemistry & biology, 2005 - cell.com
The extracellular environment is largely comprised of complex polysaccharides, which were
historically considered inert materials that hydrated the cells and contributed to the structural …
historically considered inert materials that hydrated the cells and contributed to the structural …
3‐O‐Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake
J Zhao, Y Zhu, X Song, Y Xiao, G Su… - Angewandte Chemie …, 2020 - Wiley Online Library
Prion‐like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by tau
binding to cell surface heparan sulfate (HS). However, the structural determinants for tau …
binding to cell surface heparan sulfate (HS). However, the structural determinants for tau …
[HTML][HTML] Heparan sulfate 3-O-sulfation: a rare modification in search of a function
BE Thacker, D Xu, R Lawrence, JD Esko - Matrix Biology, 2014 - Elsevier
Many protein ligands bind to heparan sulfate, which results in their presentation, protection,
oligomerization or conformational activation. Binding depends on the pattern of sulfation and …
oligomerization or conformational activation. Binding depends on the pattern of sulfation and …