Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing
and adult organism. The accumulated wealth of structural information on the FGF signalling …

Heparin, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has
numerous important biological activities, associated with its interaction with diverse proteins …

Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and
metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members …

Unique among fibroblast growth factors (FGFs), FGF19,-21, and-23 act in an endocrine
fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis …

Fibroblast growth factors (FGFs) signal in a paracrine or endocrine fashion to mediate a
myriad of biological activities, ranging from issuing developmental cues, maintaining tissue …

The extracellular environment is largely comprised of complex polysaccharides, which were
historically considered inert materials that hydrated the cells and contributed to the structural …

Prion‐like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by tau
binding to cell surface heparan sulfate (HS). However, the structural determinants for tau …

Many protein ligands bind to heparan sulfate, which results in their presentation, protection,
oligomerization or conformational activation. Binding depends on the pattern of sulfation and …