Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a
valuable model system to study the generation and mechanisms modulating conventional …

Introduction: Aqueous humor and its dynamics (AHD) serve numerous functions to sustain
ocular health and clear vision. Current methods to assess AHD have led to improved …

Purpose.: To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT)
in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including …

Glaucoma is a common cause of vision loss or blindness and reduction of intraocular
pressure (IOP) has been proven beneficial in a large fraction of glaucoma patients. The IOP …

Elevated intraocular pressure (IOP) is the predominant risk factor for glaucoma, and
reducing IOP is the only successful strategy to prevent further glaucomatous vision loss. IOP …

Purpose.: To determine the connections between the ciliary muscle (CM), trabecular
meshwork (TM), and Schlemm's canal (SC) and their innervations that allows CM …

Elevated intraocular pressure (IOP) is the best recognized risk factor for the pathogenesis of
glaucoma and the extent of retinal ganglion cell (RGC) degeneration in glaucoma is closely …

Purpose.: An intracanalicular scaffold (Hydrus microstent) designed to reduce intraocular
pressure as a glaucoma treatment was tested in human anterior segments to determine …

Purpose.: Mouse models are useful for glaucoma research, but it is unclear whether
intraocular pressure (IOP) regulation in mice operates through mechanisms similar to those …

Purpose: We evaluated differences in aqueous humor dynamics (AHD) among several
mouse strains within younger and older age groups. Methods: Albino (A/J, BALB/cJ) and …