Tuberculosis (TB) in humans is caused by Mycobacterium tuberculosis (Mtb). It is estimated
that 70 million children (< 15 years) are currently infected with Mtb, with 1.2 million each year …

Children represent both a clinically important population susceptible to tuberculosis and a
key group in whom to study intrinsic and vaccine-induced mechanisms of protection. After …

In an accident later known as the Lübeck disaster, 251 neonates were orally given three
doses of the new Bacille Calmette–Guérin (BCG) antituberculosis (TB) vaccine …

The clinical expression of disease caused by Mycobacterium tuberculosis is greatly different
in infants, children, and adolescents from what it is in adults (1, 2). Much adult pulmonary …

Background Following exposure to TB, contacts are screened to target preventive treatment
at those at high risk of developing TB. The UK has recently revised its recommendations for …

In 2015, there were an estimated 10.4 million new cases of tuberculosis (TB) globally,
making it one of the leading causes of death due to an infectious disease. TB is caused by …

Millions of children are exposed to tuberculosis (TB) each year, many of which become
infected with Mycobacterium tuberculosis. Most children can immunologically contain or …

Rationale: Interferon-γ (IFN-γ) release assays are widely used to diagnose latent infection
with Mycobacterium tuberculosis in adults, but their performance in children remains …

Research into novel immunological biomarkers, and greater understanding of the complex
network of interactions between the innate and adaptive immune systems, is key to …

Following exposure to tuberculosis and subsequent infection, children often progress to
tuberculosis disease more rapidly than adults. And yet the natural history of tuberculosis in …