The hepatic immune system is constantly exposed to a massive load of harmless dietary and
commensal antigens, to which it must remain tolerant. Immune tolerance in the liver is …

Biliary atresia is a severe cholangiopathy of early infancy that destroys extrahepatic bile
ducts and disrupts bile flow. With a poorly defined disease pathogenesis, treatment consists …

The liver is an organ in which several major pathogens evade immune clearance and
achieve chronicity. How do they do it? Recent research has documented multiple …

Background and aims Perinatal cytomegalovirus (CMV) infection is a possible cause or
trigger of biliary atresia though clinical evidence is scant. We hypothesised that CMV IgM+ …

Biliary atresia (BA) is a devastating fibro-inflammatory disease characterized by the
obstruction of extrahepatic and intrahepatic bile ducts in infants that can have fatal …

Biliary atresia (BA) is a rare disease of unknown etiology and unpredictable outcome, even
when there has been timely diagnosis and exemplary surgery. It has been the commonest …

The liver is an important immunological organ that controls systemic tolerance. The liver
harbors professional and unconventional antigen-presenting cells that are crucial for …

Drug-induced liver injury includes a spectrum of pathologies, some related to the mode of
injury, some to the cell type primarily damaged. Among these, drug-induced bile duct injury …

The liver is an immunoregulatory organ in which a tolerogenic microenvironment mitigates
the relative “strength” of local immune responses. Paradoxically, necro-inflammatory …

Cholangiocytes express antigen‐presenting molecules, but it has been unclear whether
they can present antigens. Natural killer T (NKT) cells respond to lipid antigens presented by …