Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …

[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Molecular mechanisms and cellular contribution from lung fibrosis to lung cancer development

AV Samarelli, V Masciale, B Aramini, GP Coló… - International journal of …, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of …

Comorbidities in idiopathic pulmonary fibrosis: an underestimated issue

A Caminati, C Lonati, R Cassandro… - European …, 2019 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive and fibrosing lung disease with a poor
prognosis. Between 60% and 70% of IPF patients die of IPF; the remaining causes of death …

Immune checkpoint inhibitor-related pneumonitis

G Gomatou, V Tzilas, E Kotteas, K Syrigos, D Bouros - Respiration, 2021 - karger.com
Immune checkpoint inhibitors are novel agents that have been proved efficacious in a
variety of cancer types, but they are associated with a unique set of organ-specific, immune …

Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway

Y Lu, W Zhong, Y Liu, Z Zeng, H Huang, X Wan… - International …, 2022 - Elsevier
Pulmonary fibrosis is a fatal lung disease for which no effective treatment is available.
Previous studies have shown that the expression of programmed cell death-Ligand (PD-L1) …

[HTML][HTML] Mechanical forces: The missing link between idiopathic pulmonary fibrosis and lung cancer

C Wang, J Yang - European Journal of Cell Biology, 2022 - Elsevier
Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer
compared with the general population. The morbidity of lung cancer in IPF patient ranges …

Downregulation of N6-methyladenosine-modified LINC00641 promotes EMT, but provides a ferroptotic vulnerability in lung cancer

S Xi, DJ Ming, JH Zhang, MM Guo, SY Wang… - Cell Death & …, 2023 - nature.com
The prognosis of lung cancer is poor with few effective therapies. Targeting ferroptosis is a
new promising strategy for cancer therapy. LINC00641 has been involved in several …

Mesenchymal stem cell-derived extracellular vesicles as idiopathic pulmonary fibrosis microenvironment targeted delivery

L Sang, X Guo, H Fan, J Shi, S Hou, Q Lv - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) affects an increasing number of people globally, yet
treatment options remain limited. At present, conventional treatments depending on drug …

Dendritic cells are the intriguing players in the puzzle of idiopathic pulmonary fibrosis pathogenesis

M Bocchino, S Zanotta, L Capitelli, D Galati - Frontiers in Immunology, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is the most devastating progressive interstitial lung
disease that remains refractory to treatment. Pathogenesis of IPF relies on the aberrant cross …