It is axiomatic in medicinal chemistry that optimization of the potency of a small molecule at a
macromolecular target requires complementarity between the ligand and target. In order to …

Intramolecular nucleophilic aromatic substitution (Truce–Smiles rearrangement) of the
anions of 2‐benzyl benzanilides leads to triarylmethanes in an operationally simple manner …

The acidities (p K a values) of proline amide derivatives are of great importance for
understanding the catalytic activity of proline-based organocatalysts. The development of …

Reversible encapsulation complexes are applied to the reaction of isonitriles with carboxylic
acids. Encapsulation facilitates these reactions by amplifying the concentration of reactants …

The conformational preferences of 28 sterically and electronically diverse N-aryl amides
were determined using density functional theory (DFT), using the B3LYP functional and 6 …

To search for new antiestrogens more effective in treating breast cancers, we explored
alternatives to the acrylic acid side chain used in many antiestrogens. To facilitate our …

The reverse anomeric effect is usually associated with the equatorial preference of nitrogen
substituents at the anomeric center. Once postulated as another anomeric effect with …

Glucokinase (GK) is the rate-limiting step for insulin release from the pancreas in response
to high levels of glucose. Flux through GK also contributes to reducing hepatic glucose …

This paper explores and revisits in detail the formation and characterization of sugar-based
aminonitriles, whose ultimate origin can be traced to the interaction of biomolecules with …

Secondary formamides are widely encountered in biology and exist as mixtures of both cis
and trans isomers. Here, we assess hydrophilicity differences between isomeric formamides …