[HTML][HTML] Multimodal biomedical AI

JN Acosta, GJ Falcone, P Rajpurkar, EJ Topol - Nature Medicine, 2022 - nature.com
The increasing availability of biomedical data from large biobanks, electronic health records,
medical imaging, wearable and ambient biosensors, and the lower cost of genome and …

Microbiota succession throughout life from the cradle to the grave

C Martino, AH Dilmore, ZM Burcham… - Nature Reviews …, 2022 - nature.com
Associations between age and the human microbiota are robust and reproducible. The
microbial composition at several body sites can predict human chronological age relatively …

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

CN Spencer, JL McQuade, V Gopalakrishnan… - Science, 2021 - science.org
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in
cancer, but the effect of diet and supplements on this interaction is not well studied. We …

[HTML][HTML] Greengenes2 unifies microbial data in a single reference tree

D McDonald, Y Jiang, M Balaban, K Cantrell… - Nature …, 2024 - nature.com
Studies using 16S rRNA and shotgun metagenomics typically yield different results, usually
attributed to PCR amplification biases. We introduce Greengenes2, a reference tree that …

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

JA McCulloch, D Davar, RR Rodrigues, JH Badger… - Nature medicine, 2022 - nature.com
Ample evidence indicates that the gut microbiome is a tumor-extrinsic factor associated with
antitumor response to anti-programmed cell death protein-1 (PD-1) therapy, but …

Targeting the gut microbiota for cancer therapy

MR Fernandes, P Aggarwal, RGF Costa… - Nature Reviews …, 2022 - nature.com
Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …

Host variables confound gut microbiota studies of human disease

I Vujkovic-Cvijin, J Sklar, L Jiang, L Natarajan, R Knight… - Nature, 2020 - nature.com
Low concordance between studies that examine the role of microbiota in human diseases is
a pervasive challenge that limits the capacity to identify causal relationships between host …

[HTML][HTML] Metagenomics-enabled microbial surveillance

KKK Ko, KR Chng, N Nagarajan - Nature Microbiology, 2022 - nature.com
Lessons learnt from the COVID-19 pandemic include increased awareness of the potential
for zoonoses and emerging infectious diseases that can adversely affect human health …

Gut microbiome composition may be an indicator of preclinical Alzheimer's disease

AL Ferreiro, JH Choi, J Ryou, EP Newcomer… - Science translational …, 2023 - science.org
Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …

[HTML][HTML] The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …