Lung cancer (LC) is considered as one of the leading causes of cancer-associated
mortalities. Cancer cells' reprogrammed metabolism results in changes in metabolite …

Purpose To compile a list of genes that have been reported to be affected by external
ionizing radiation (IR) and to assess their performance as candidate biomarkers for …

Differential mRNA expression studies implicitly assume that changes in mRNA expression
have biological meaning, most likely mediated by corresponding changes in protein levels …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with marked
chemoresistance and a 5-year survival rate of 7%. The integrated stress response (ISR) is a …

Objectives Epigenetic alterations have been implicated in the development of platinum
resistance in ovarian cancer (OC). In this study, we aimed to identify DNA methylation …

Inevitable tumor recurrence and a poor median survival are frustrating reminders of the
inefficacy of our current standard of care for patients with newly diagnosed glioblastoma …

Background Following neoadjuvant chemotherapy for operable gastroesophageal cancer,
lymph node metastasis is the only validated prognostic variable; however, within lymph …

Cancer heterogeneity poses a significant hurdle to the successful treatment of the disease,
and is being influenced by genetic inheritance, cellular and tissue biology, disease …

Abstract Deregulated IGF-1R-AKT signaling influences multiple nodes of cancer cell
physiology and assists in migration, metastasis and acquirement of radio/chemoresistance …

Chromatin undergoes structural changes in response to extracellular and environmental
signals. We observed changes in nuclear morphology in cancer tissue biopsied after …