[HTML][HTML] Neuroblastoma and the epigenome

IS Fetahu, S Taschner-Mandl - Cancer and Metastasis Reviews, 2021 - Springer
Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the
most common solid tumors in infancy. Amplification of MYCN, copy number alterations …

Cancer epigenetics: modifications, screening, and therapy

GY Einav Nili, Y Saito, G Egger, PA Jones - Annu. Rev. Med., 2008 - annualreviews.org
Deregulation of gene expression is a hallmark of cancer. Although genetic lesions have
been the focus of cancer research for many years, it has become increasingly recognized …

The CpG island methylator phenotype: what's in a name?

LAE Hughes, V Melotte, J De Schrijver, M De Maat… - Cancer research, 2013 - AACR
Although the CpG island methylator phenotype (CIMP) was first identified and has been
most extensively studied in colorectal cancer, the term “CIMP” has been repeatedly used …

The connections between neural crest development and neuroblastoma

M Jiang, J Stanke, JM Lahti - Current topics in developmental biology, 2011 - Elsevier
Neuroblastoma (NB), the most common extracranial solid tumor in childhood, is an
extremely heterogeneous disease both biologically and clinically. Although significant …

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

M Berdasco, S Ropero, F Setien… - Proceedings of the …, 2009 - National Acad Sciences
Sotos syndrome is an autosomal dominant condition characterized by overgrowth resulting
in tall stature and macrocephaly, together with an increased risk of tumorigenesis. The …

Integrative genome-scale analysis identifies epigenetic mechanisms of transcriptional deregulation in unfavorable neuroblastomas

KO Henrich, S Bender, M Saadati, D Dreidax… - Cancer research, 2016 - AACR
The broad clinical spectrum of neuroblastoma ranges from spontaneous regression to rapid
progression despite intensive multimodal therapy. This diversity is not fully explained by …

DNA methylation as a marker for the past and future

T Ushijima, T Nakajima, T Maekita - Journal of gastroenterology, 2006 - Springer
Aberrant methylation of CpG islands in promoter regions can permanently inactivate tumor-
suppressor genes, as mutations and chromosomal abnormalities do. In gastric cancers …

CpG island methylator phenotype (CIMP) in cancer: causes and implications

JM Teodoridis, C Hardie, R Brown - Cancer letters, 2008 - Elsevier
Strong evidence exists for a subgroup of tumours, from a variety of tissue types, exhibiting
concordant tumour specific DNA methylation: the “CpG island methylator phenotype”(CIMP) …

[HTML][HTML] EZH2 regulates neuroblastoma cell differentiation via NTRK1 promoter epigenetic modifications

Z Li, H Takenobu, AN Setyawati, N Akita, M Haruta… - Oncogene, 2018 - nature.com
The polycomb repressor complex 2 molecule EZH2 is now known to play a role in essential
cellular processes, namely, cell fate decisions, cell cycle regulation, senescence, cell …

Epigenetic regulation of neuroblastoma development

K Durinck, F Speleman - Cell and Tissue Research, 2018 - Springer
In recent years, technological advances have enabled a detailed landscaping of the
epigenome and the mechanisms of epigenetic regulation that drive normal cell function …