Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

While there have been rapid advances in developing new and more targeted drugs to treat
cancer, much less progress has been made in individualizing dosing. Even though the …

The development of Pharmacogenetics and Pharmacogenomics in Western Europe is
highly relevant in the worldwide scenario. Despite the usually low institutional support, many …

The phenomenon of drug resistance has been a hindrance to therapeutic medicine since
the late 1940s. There is a plethora of factors and mechanisms contributing to progression of …

Mycophenolic acid (MPA) is a potent antiproliferative drug prescribed to prevent acute
rejection in kidney transplantation. MPA reversibly inhibits the enzymes involved in the …

This work aimed to analyse the pharmacogenetic information in the Spanish Drug
Regulatory Agency (AEMPS) Summary of Products Characteristics (SmPC), evaluating the …

Single nucleotide polymorphisms (SNPs) in Pharmacogenetics can play an important role in
the outcomes of the chemotherapy treatment in Neuroblastoma, helping doctors maximize …

Introducción La enfermedad oncohematológica continúa siendo la primera causa de
mortalidad no traumática en la infancia y una importante causa de morbilidad. El paciente …

Over the years, cancer research has focused on different strategies to discover drugs and
therapies to treat the metastatic stage of cancer. This stage depends upon the type, and the …

The appearance of drug resistance represents a significant problem for the clinical
management of patients with several malignancies. The lack of response culminates in more …