Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …

Phytochemicals refer to active substances in plant-based diets. Phytochemicals found in for
example fruits, vegetables, grains and seed oils are considered relatively safe for …

Piperine is the main compound present in black pepper, and is the carrier of its specific
pungent taste, which is responsible for centuries of human dietary utilization and worldwide …

Depression is a common and serious mental disorder. Data on its pathogenesis remain
unclear and the options of drug treatments are limited. Here, we explored the role of …

Depression is a prevalent psychiatric disorder and a leading cause of disability worldwide.
Despite a variety of available treatments currently being used in the clinic, a substantial …

Piperine (PIP) is a natural alkaloid isolated from Piper longum L. that presents antioxidant,
anticonvulsant, antimicrobial, neuroprotective, larvicidal, antiparasitic, anticancer effect and …

Objectives Bilateral destruction of the olfactory bulbs is known to cause behavioral changes
analogous to symptoms of depression. Curcumin, a traditional Indian spice is currently being …

Aging-related cholinergic dysfunction, extensive neuroinflammation and oxidative stress in
brain are predominant pathogenic factors for dementia. In the present study, we aimed to …

Recently, we reported that chronic nicotine significantly improved chronic stress-induced
impairments of cognition and the hippocampal synaptic plasticity in mice, however, the …

Post natal exposure to VPA (valproic acid) in mice induces behavioral deficits, abnormal
sensitivity to sensory stimuli and self-injurious behavior, observed in autism. Piperine has …