The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …

Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully
produce haploid gametes. To date, only a handful of meiotic SUMO targets have been …

Programmed DNA double-strand break (DSB) formation is a crucial feature of meiosis in
most organisms. DSBs initiate recombination-mediated linking of homologous …

Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …

Sexually reproducing eukaryotes use recombination between homologous chromosomes to
promote chromosome segregation during meiosis. Meiotic recombination is almost …

Proper number and placement of meiotic crossovers is vital to chromosome segregation,
with failures in normal crossover distribution often resulting in aneuploidy and infertility …

The formation of crossovers between homologous chromosomes is key to sexual
reproduction. In most species, crossovers are spaced further apart than would be expected if …

DNA mismatch repair (MMR) corrects non-Watson-Crick basepairs generated by replication
errors, recombination intermediates, and some forms of chemical damage to DNA. In MutS …

Genetic recombination arises during meiosis through the repair of DNA double-strand
breaks (DSBs) that are created by Spo11, a topoisomerase-like protein,. Spo11 DSBs form …