When DNA double-strand breaks occur, the cell cycle stage has a major influence on the
choice of the repair pathway employed. Specifically, nonhomologous end joining is the …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

The list of long non-coding RNAs (lncRNAs) involved in the p53 pathway of the DNA
damage response is rapidly expanding, but whether lncRNAs have a role in maintaining the …

Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may
contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced …

To cope with DNA double strand break (DSB) genotoxicity, cells have evolved two main
repair pathways: homologous recombination which uses homologous DNA sequences as …

DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result
in cell death or genomic instability. DSB repair is usually facilitated by the classical non …

The repair of toxic double-strand breaks (DSB) is critical for the maintenance of genome
integrity. The major mechanisms that cope with DSB are: homologous recombination (HR) …

Objective: Although HAART effectively suppresses viral replication, it fails to eradicate latent
viral reservoirs. The 'shock and kill'strategy involves the activation of HIV from latent …

The interplay between active biological processes and DNA repair is central to mutagenesis.
Here, we show that the ubiquitous process of replication initiation is mutagenic, leaving a …

DNA double‐strand breaks (DSB s) are highly toxic lesions that can lead to profound
genome rearrangements and/or cell death. They routinely occur in genomes due to …