Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …

Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …

A new series of sulfonamides, 8a-b, 10, 12, and 14a-b, were synthesized by N-sulfonation
reaction with sulfonyl chlorides 6a-b. Five new series of chalcone-sulfonamide hybrids (16 …

Abstract Introduction: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is
characterized by the sudden onset of severe obsessive-compulsive symptoms and/or eating …

Pyrazolines are important five‐membered heterocycles, containing two adjacent nitrogen
atoms. They can incorporate various functional groups and possess unique biological …

Within the past years, many researches on the synthesis, structure-activity relationships
(SAR), antitumor, antiinflammatory and anti-bacterial activities of the pyrazole derivatives …

A series of pyrazoline derivatives (5) were synthesized in 92–96% yields from chalcones (3)
and hydrazides (4). Subsequently, topo-I and IIα-mediated relaxation and antiproliferative …

A novel phosphine-catalyzed [3+ 2] cycloaddition of α-diazoacetates and β-trifluoromethyl
enones has been developed that provides facile access to multisubstituted 4 …

Objective: Accumulating evidence suggests that anti-inflammatory interventions can
modulate neuropsychiatric symptoms. Pediatric Acute-onset Neuropsychiatric Syndrome …

Inflammation plays an important role in the pathophysiology of Chagas disease, caused by
Trypanosoma cruzi. Prostanoids are regulators of homeostasis and inflammation and are …