From being a niche area only a few decades ago, fluorous chemistry has gained momentum
and is, nowadays, a fervent area of research. It has brought forth, in fact, numerous …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

The broad study of histone deacetylases in chemistry, biology and medicine relies on tool
compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone …

Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of
protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded …

The transcription factor MYC plays a pivotal role in cancer initiation, progression, and
maintenance. However, it has proven difficult to develop small molecule inhibitors of MYC …

Perfluorocarbons, saturated carbon chains in which all the hydrogen atoms are replaced
with fluorine, form a separate phase from both organic and aqueous solutions. Though …

We describe a Nanostructure-Initiator Mass Spectrometry (NIMS) enzymatic (Nimzyme)
assay in which enzyme substrates are immobilized on the mass spectrometry surface by …

Long-term memory formation is known to be critically dependent upon de novo gene
expression in the brain. As a consequence, pharmacological enhancement of the …

The discovery of small molecules that bind to a specific target and disrupt the function of
proteins is an important step in chemical biology, especially for poorly characterized …

RNA is crucial for gene expression and regulation. Recent advances in understanding of
RNA biochemistry, structure and molecular biology have revealed the importance of RNA …