The fluorous effect in biomolecular applications
From being a niche area only a few decades ago, fluorous chemistry has gained momentum
and is, nowadays, a fervent area of research. It has brought forth, in fact, numerous …
and is, nowadays, a fervent area of research. It has brought forth, in fact, numerous …
Survey of the year 2007 commercial optical biosensor literature
RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2008 - Wiley Online Library
In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …
Reported developments in instrument hardware, assay design, and immobilization …
Chemical phylogenetics of histone deacetylases
JE Bradner, N West, ML Grachan… - Nature chemical …, 2010 - nature.com
The broad study of histone deacetylases in chemistry, biology and medicine relies on tool
compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone …
compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone …
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma
T Hideshima, J Qi, RM Paranal… - Proceedings of the …, 2016 - National Acad Sciences
Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of
protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded …
protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded …
Small molecule microarrays enable the identification of a selective, quadruplex-binding inhibitor of MYC expression
KM Felsenstein, LB Saunders, JK Simmons… - ACS chemical …, 2016 - ACS Publications
The transcription factor MYC plays a pivotal role in cancer initiation, progression, and
maintenance. However, it has proven difficult to develop small molecule inhibitors of MYC …
maintenance. However, it has proven difficult to develop small molecule inhibitors of MYC …
Perfluorocarbons in chemical biology
MA Miller, EM Sletten - ChemBioChem, 2020 - Wiley Online Library
Perfluorocarbons, saturated carbon chains in which all the hydrogen atoms are replaced
with fluorine, form a separate phase from both organic and aqueous solutions. Though …
with fluorine, form a separate phase from both organic and aqueous solutions. Though …
A nanostructure-initiator mass spectrometry-based enzyme activity assay
TR Northen, JC Lee, L Hoang… - Proceedings of the …, 2008 - National Acad Sciences
We describe a Nanostructure-Initiator Mass Spectrometry (NIMS) enzymatic (Nimzyme)
assay in which enzyme substrates are immobilized on the mass spectrometry surface by …
assay in which enzyme substrates are immobilized on the mass spectrometry surface by …
Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity
Long-term memory formation is known to be critically dependent upon de novo gene
expression in the brain. As a consequence, pharmacological enhancement of the …
expression in the brain. As a consequence, pharmacological enhancement of the …
A small-molecule inhibitor shows that pirin regulates migration of melanoma cells
I Miyazaki, S Simizu, H Okumura, S Takagi… - Nature chemical …, 2010 - nature.com
The discovery of small molecules that bind to a specific target and disrupt the function of
proteins is an important step in chemical biology, especially for poorly characterized …
proteins is an important step in chemical biology, especially for poorly characterized …
Targeting RNA structures in diseases with small molecules
Y Shao, QC Zhang - Essays in Biochemistry, 2020 - portlandpress.com
RNA is crucial for gene expression and regulation. Recent advances in understanding of
RNA biochemistry, structure and molecular biology have revealed the importance of RNA …
RNA biochemistry, structure and molecular biology have revealed the importance of RNA …