It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Summary In our 24/7 well-lit world, it's easy to skip or delay sleep to work, study, and play.
However, our circadian rhythms are not easily fooled; the consequences of jet lag and shift …

The quiescent center (QC) maintains the activity of the surrounding stem cells within the root
stem cell niche, yet specific molecular players sustaining the low rate of QC cell division …

Reaction networks displaying bistability provide a chemical mechanism for long-term
memory storage in cells, as exemplified by many epigenetic switches. These biological …

Multi-component signal transduction pathways and gene regulatory circuits underpin
integrated cellular responses to perturbations. A recurring set of network motifs serve as the …

Chemical reaction systems are dynamical systems that arise in chemical engineering and
systems biology. In this work, we consider the question of whether the minimal (in a precise …

Bistable switches are fundamental regulatory elements of complex systems, ranging from
electronics to living cells. Designed genetic toggle switches have been constructed from …

Which reaction networks, when taken with mass-action kinetics, have the capacity for
multiple steady states? There is no complete answer to this question, but over the last 40 …

A toggle switch consists of two genes that mutually repress each other. This regulatory motif
is active during cell differentiation and is thought to act as a memory device, being able to …

This paper provides a framework to represent a Biochemical Systems Theory (BST) model
(in either GMA or S-system form) as a chemical reaction network with power law kinetics …