As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …

Inflammation is a variable feature of osteoarthritis (OA), associated with joint symptoms and
progression of disease. Signs of inflammation can be observed in joint fluids and tissues …

Objective Obesity is a growing epidemic in the world. It increases the risk for severe health
conditions, including diabetes, heart disease and stroke. Recent research has found that …

Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …

Further work on mediators and pathways that are common across different models and
occur in human osteoarthritis and that impact the osteoarthritis disease process at different …

Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint
loading–associated to obesity, malalignment, trauma or joint instability–is a critical risk factor …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Metabolic syndrome-associated osteoarthritis : Current Opinion in Rheumatology Metabolic
syndrome-associated osteoarthritis : Current Opinion in Rheumatology Log in or Register …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …