Peptide identification in liquid chromatography-tandem mass spectrometry (LC-MS/MS)
experiments relies on computational algorithms for matching acquired MS/MS spectra …

Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) is
treated with ALK tyrosine kinase inhibitors (TKIs), but the lack of activity of immune …

The immunopeptidome is the repertoire of peptides bound and presented by the MHC class
I, class II, and non-classical molecules. The peptides are produced by the degradation of …

The 'MHC-I (major histocompatibility complex class I)-opathy'concept describes a family of
inflammatory conditions with overlapping clinical manifestations and a strong genetic link to …

Serial multi-omic analysis of proteome, phosphoproteome, and acetylome provides insights
into changes in protein expression, cell signaling, cross-talk and epigenetic pathways …

T cell recognition of human leukocyte antigen (HLA)-presented tumor-associated peptides is
central for cancer immune surveillance. Mass spectrometry (MS)-based immunopeptidomics …

Human leukocyte antigen (HLA) class I peptide ligands (HLAIps) are key targets for
developing vaccines and immunotherapies against infectious pathogens or cancer cells …

Cancers avoid immune surveillance through an array of mechanisms, including perturbation
of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I …

Mass spectrometry (MS)-based immunopeptidomics is an attractive antigen discovery
method with growing clinical implications. However, the current experimental approach to …

In autoimmune diseases, recognition of self-antigens presented by major histocompatibility
complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or …