Nature often uses cascade reactions in a highly stereocontrolled manner for assembly
structurally diverse nitrogen-containing heterocyclic scaffolds, ie secondary metabolites …

Arsenicals were introduced as monotherapies for the treatment of human African
trypanosomiasis, or sleeping sickness, over 100 years ago. Toxicity has always been an …

Fatal if untreated, human African trypanosomiasis (HAT; sleeping sickness) afflicts an
estimated 50,000–70,000 people each year [1], all in sub-Saharan Africa, with only a …

There is a dramatic resurgence of human African trypanosomiasis (HAT) in sub-Saharan
Africa. Tb gambiense is spreading epidemically in large areas of Central Africa, especially …

Background. Existing diagnostic and treatment tools for human African trypanosomiasis
(HAT) are limited. The recent development of nifurtimox-eflornithine combination therapy …

Encephalopathies are the most feared complications of sleeping sickness treatment with
melarsoprol. To investigate the existence of risk factors, the incidence of encephalopathic …

Human African trypanosomiasis (HAT), or sleeping sickness, is currently on the rise. HAT
develops in two stages, the first involving the hemolymphatic system, and the second, the …

Abstract Background. Human African trypanosomiasis caused by Trypanosoma brucei
gambiense is a fatal disease. Current treatment options for patients with second-stage …

Pharyngitis is an inflammation of the mucous membranes and underlying structures of the
throat. Acute pharyngitis is one of the most common illnesses for which children visit primary …

Resistance to currently used drugs is a serious problem in most fields of antimicrobial
chemotherapy. Crossresistance between two of the major classes of drug used in the …